Wnt Signaling During Cardiomyocyte Differentiation
Description
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Cardiomyocytes can be generated from induced pluripotent stem cells (iPSC) by mimicking embryonic cardiogenesis. The Wnt signaling pathway plays a crucial role in cardiac tissue differentiation. Wnt signaling during the first days of cell culture increases the half-life of β-catenin’s enabling its action as a transcription factor. Inhibiting this pathway at the mesoderm phase allows differentiation to continue until spontaneous beating begins. Following this, Wnt activation is resumed.
Acknowledgements
References
Lian, X. et. al. (2013) Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nature Protocols. https://doi.org/10.1038/nprot.2012.150
Später, D. et. al. (2014) How to make a cardiomyocyte. Development. https://dev.biologists.org/content/141/23/4418
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