Waddington’s landscape, transdifferentiation and reprograming
Description
Waddington applied the same reasoning in his Landscape. It describes a ball, representing a stem cell, rolling down a hill marked by uneven slopes and valleys. In this metaphor, the hill represents the cell differentiation process and slopes and valleys ultimately channel the ball towards the terminal differentiation.
Acknowledgements
References
Yamanaka, S. Elite and stochastic models for induced pluripotent stem cell generation. Nature 460, 49-52 (2009).
Waddington, CH. The Strategy of the Genes. A Discussion of Some Aspects of Theoretical Biology (Alen & Unwin, 1957).
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