Vitamin D Deficiency Impacts Immunity in the Gut
Description
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Vitamin D is a key regulator of gastrointestinal immunity. Vitamin D deficiency leads to a disruption in the intestinal barrier, allowing Proteobacteria to enter the lamina propria and cause severe inflammation. Futhermore, a lack of vitamin D leads to an increase in secretion of pro-inflammatory cytokines including IL-17 and IFNy and a decrease in anti-inflammatory cytokines such as IL-10 and IL-22. Together, these result in compromised immune responses.
Acknowledgements
References
Cantorna, M. T., Snyder, L., & Arora, J. (2019). Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Critical reviews in biochemistry and molecular biology, 54(2), 184-192.
https://doi.org/10.1080/10409238.2019.1611734
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