Vasculogenesis and Angiogenesis
Description
A visualization of the two vascularization processes: vasculogenesis and angiogenesis. In vasculogenesis, de novo blood vessel formation occurs when endothelial precursor cell and hematopoietic stem cell aggregates migrate to form a lumen. Angiogenesis involves new blood vessel formation from pre-existing vessels. Angiogenesis: proteolytic breakdown of basement membrane and detachment of mural cells, tip cell formation to guide vessel formation, stalk-cells elongating to form the new lumen
Acknowledgements
References
Carmeliet P & Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473: 298–307
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