Vagal afferents detect various gut-derived signals at multiple visceral sites.
Description
Mechanical distension and mucosal stroking can be sensed across the alimentary canal, including the esophagus, stomach, and intestine. Chemical stimuli can be detected within the intestine. Post-absorptive signals, such as glucose and osmolytes, can be monitored by vagal afferents that innervate the hepatic portal area. Additionally, vagal afferents innervating the pancreas can detect 5-HT secreted by the pancreatic beta cells after glucose absorption.
Acknowledgements
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