Urocortin-2 (Ucn-2) Protects Against Myocardial Infarction

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia/Reperfusion (I/R). We show a translational study for acute myocardial infarction using I/R rat model with Ligation Coronary Artery (LCA). The study is focused on Store Operated Ca2+ Entry (SOCE) which is a central mechanism in Ca2+ signalling. Orai1 and TRPC5 are store operated Ca2+ channels which are overexpressed and colocalizated in I/R. Ucn-2 is able to act on these pathways and is proposed as a new cardioprotector.

Acknowledgements

References

Domínguez-Rodríguez, A., Mayoral-Gonzalez, I., Avila-Medina, J., et al. (2018). Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion. Frontiers in physiology, 9, 813. https://doi.org/10.3389/fphys.2018.00813

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