Ultracentrifugation Of A Plasma Sample
Description
A visualization of the separation of protein-bound drug molecules from unbound (free) drug molecules using ultracentrifugation. Proteins and other dense plasma components will segregate at the bottom. Most freely dissloved small molecules will be in the middle, aqueous layer while low density molecules such as lipids will form the top layer.
Acknowledgements
References
1. Bowman, C. M., & Benet, L. Z., (2018). An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. European Journal of Pharmaceutical Sciences, 123(2018), 504-514. doi:10.1016/j.ejps.2018.08.008
2. Howard, M. L., et al (2010). Plasma protein binding in drug discovery and development. Combinatorial Chemistry & High Throughput Screening, 13(2), 170-187. doi:10.2174/138620710790596745
3. Kieltyka, K., et al (2016). Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination. Journal of Pharmaceutical Sciences, 105(3), 1036-1042. doi:10.1016/s0022-3549(15)00177-x
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