TXNRD1 and NRF2 pathway activation in tumor recurrence in NSCLC

Description

Activating mutations in the KEAP1/NRF2 pathway characterize a subset of non-small cell lung cancer (NSCLC) associated with chemoresistance and poor prognosis. We herein evaluated the relationship between 64 oxidative stress-related genes and overall survival data from 35 lung cancer datasets. Thioredoxin reductase-1 (TXNRD1) stood out as the most significant predictor of poor outcome.

Acknowledgements

References

YAN, Xiang et al. Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis. Cancer research, v. 79, n. 1, p. 125-132, 2019. ZANOTTO-FILHO, Alfeu et al. Alkylating agent–induced NRF2 blocks endoplasmic reticulum stress–mediated apoptosis via control of glutathione pools and protein thiol homeostasis. Molecular cancer therapeutics, v. 15, n. 12, p. 3000-3014, 2016.

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