Tumor Extracellular Matrix Reduces Therapeutic Efficiency in Solid Tumors
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
The tumor microenvironment (TME) comprises all components of a tumor. Of these components, the extracellular matrix (ECM) is the least well studied. Solid tumors induce high expression of ECM molecules (collagens, proteoglycans, hyaluronic acid and laminins), which become complex and disordered, resulting in altered characteristic. Here the ECM acts as a physical barrier, reducing the delivery of therapeutics, nutrients, and immune cells to solid tumors, and leading to poorer prognosis.
Acknowledgements
References
Henke, E et al. (2020) Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy.. Frontiers in molecular bioscience. https://www.frontiersin.org/articles/10.3389/fmolb.2019.00160/full
Belli, C et al. (2018) Targeting the microenvironment in solid tumors. Cancer treatment reviews. https://pubmed.ncbi.nlm.nih.gov/29502037/
Get started with this template for freeDon’t start from scratch.
Create professional scientific illustrations quickly and easily, even without any design expertise
- Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
- Create figures that effectively communicate your research in half the time using our editable icons.
- Use our PDB tool to quickly generate and customize protein structures
.gif)
