Trophoblast organoids grown with physiologic polarity

Description

Depiction of the culturing of trophoblast organoids (TOs) containing an inward-facing syncytiotrophoblast (STB) in Matrigel. TOs are released from Matrigel and grown in suspension for ~48hrs, which generates TOs with a physiolocially relevant STB layer on the outer surface of the organoid. Schematic of STBin (left) or STBout (right) TOs representing the cellular orientation of cytotrophoblasts (CTBs, in green), extravillous trophoblasts (in blue), and the syncytiotrophoblast (in red).

Acknowledgements

References

Yang, L., E.C. Semmes, C. Ovies, C. Megli, S. Permar, J.B. Gilner, and C.B. Coyne. 2022. Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface. Elife. 11.

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