Transcription Factor AP4 Amplifies Germinal Center B Cell Responses
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
This figure demonstrates the role of AP4 in B cell proliferation in the germinal center. When AP4 is expressed, the proliferation of B cells is sustained in the dark zone of the germinal center. This process is important for the protective antibody responses against viral infection.
Acknowledgements
References
Chou, C., Verbaro, D. J., Tonc, E., Holmgren, M., Cella, M., Colonna, M., Bhattacharya, D., & Egawa, T. (2016). The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses. Immunity, 45(3), 570–582. https://doi.org/10.1016/j.immuni.2016.07.023
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