TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer
Description
Healthy cells gain unlimited replicative potential through hTERT activation or through gain of chr.8q24.3/TONSL amplification. Theses TONSL amplified cells have hyperactivated DNA repair pathway which lead to cellular imbalance. With gain of additional driver mutations theses TONSL amplified cells lead to formation of TONSL-dependent tumors. These TONSL dependent tumors can be targeted with CBL0137, a TONSL/FACT complex specific inhibitor.
Acknowledgements
References
Get started with this template for freeDon’t start from scratch.
Create professional scientific illustrations quickly and easily, even without any design expertise
- Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
- Create figures that effectively communicate your research in half the time using our editable icons.
- Use our PDB tool to quickly generate and customize protein structures
![example of using the icon library](https://cdn.prod.website-files.com/621e6f1effebfe03881da9bd/64c7c0fc322ef8c15744f235_ezgif.com-video-to-gif%20(1).gif)