The schematic diagram shows the potential role and mechanisms of CCL2 in NMO-IgG-induced damage.
Description
The binding of NMO-IgG to AQP4 on the cytomembrane of astrocytes activated various intracellular inflammatory signaling pathways.CCL2-derived peripheral CCR2+ monocytes penetrated the brain or attracted microglia/macrophages migrated toward the lesion focus close to astrocytes. The interaction of CCR2+ cells with injured astrocytes could further stimulate the release of inflammatory cytokines, forming a positive feedback cascade loop leading to more serious damage to astrocytes.
Acknowledgements
References
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