The Role of CGRP and the Trigeminal System in Migraine Pathophysiology

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The trigeminovascular system is involved in the regulation of the cranial vasculature and is a key element in the transmission of pain. A growing body of evidence indicates that the calcitonin gene-related peptide (CGRP), widely expressed in trigeminal nerve fibers, acts as a principal mediator of migraine. CGRP release from the peripheral terminals initiates a cascade of events, leading to vasodilation of the cerebral arteries and the phenotypic expression of migraine pain.

Acknowledgements

References

Edvinsson, L. (2017). t he t rigeminovascular p athway: r ole of cgrp and cgrp r eceptors in m igraine. Headache: The Journal of Head and Face Pain, 57(S2), 47–55. https://doi.org/10.1111/head.13081 Iyengar, S., Johnson, K. W., Ossipov, M. H., & Aurora, S. K. (2019). Cgrp and the trigeminal system in migraine. Headache: The Journal of Head and Face Pain, 59(5), 659–681. https://doi.org/10.1111/head.13529 Dodick, D. W. (2018). A phase‐by‐phase review of migraine pathophysiology. Headache: The Journal of Head and Face Pain, 58(S1), 4–16. https://doi.org/10.1111/head.13300

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