The possible routes of HIGS and SIGS molecules uptake in insects and fungi.
Description
SIGS molecules can take two pathways upon entry into the cell 1) long dsRNA/hpRNA molecules may process into siRNA molecules by the host itself 2) dsRNA/hpRNA may be ingested and processed by pest/pathogen RNAi machinery. Fungal pathogens soak up dsRNA molecules through haustorial complex. The dsRNA may be in the AGO-dsRNA complex form (left side). Different insect orders vary in their feeding pattern.
Acknowledgements
References
Choudry, M.W., et . al. (2024) RNA based gene silencing modalities to control insect and fungal plant pests – Challenges and future prospects. Physiological and Molecular Plant Pathology
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