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An editable high resolution scientific image depicting The physiological basis of the fMRI BOLD response

The physiological basis of the fMRI BOLD response

Description

A complex interplay of events that lead to the generation of the BOLD signal, elicited by a stimulus. This induces a complex cascade of processes which are part of the neurovascular coupling signaling. That produces a haemodynamic response that is influenced by multiple factors that modify the [oxyHb]:[deoxyHb] ratio, resulting in changes in the inhomogeneity in the magnetic field, detected as a T2*-weighted signal by the MRI scanner, representing the functional MRI BOLD response.

Acknowledgements

References

1. Buchbinder BR. Functional magnetic resonance imaging. Handb Clin Neurol. 2016;135:61-92. doi:10.1016/B978-0-444-53485-9.00004-0 2. Tsvetanov KA, Henson RNA, Rowe JB. Separating vascular and neuronal effects of age on fMRI BOLD signals. Philos Trans R Soc Lond B Biol Sci. Jan 4 2021;376(1815):20190631. doi:10.1098/rstb.2019.0631
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