The Key Role of Neuroinflammation in Neurodegenerative Diseases
Description
The resting microglia (M0) are over-activated by PAMPs/DAMPs into a pro-inflammatory state (M1), which leads to the generation of pro-inflammatory cytokines. The treatment of anti-inflammatory drugs can inhibit the over-activation of microglia and promote the microglia into an anti-inflammatory state to maintain the balance of M1/M2 type microglia.
Acknowledgements
References
Schächtle, M. A., & Rosshart, S. P. (2021). The microbiota-gut-brain axis in health and disease and its implications for translational research. Frontiers in Cellular Neuroscience, 256.
https://doi.org/10.3389/fncel.2021.698172
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