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An editable high resolution scientific image depicting The General Stress Response in Alphaproteobacteria

The General Stress Response in Alphaproteobacteria

Description

This is a partner switch mechanism that regulates the general stress response in Alphaproteobacteria. The anti-anti-sigma factor binds the anti-sigma factor to release it from the sigma factor during stress, causing the regulon of the sigma factor to be activated.

Acknowledgements

References

Campagne, S., Damberger, F. F., Kaczmarczyk, A., Francez-Charlot, A., Allain, F. H.-T., & Vorholt, J. A. (2012). Structural basis for sigma factor mimicry in the general stress response of Alphaproteobacteria. Proceedings of the National Academy of Sciences, 109(21). https://doi.org/10.1073/pnas.1117003109 Fiebig, A., Herrou, J., Willett, J., & Crosson, S. (2015). General Stress Signaling in the Alphaproteobacteria. Annual Review of Genetics, 49(1), 603–625. https://doi.org/10.1146/annurev-genet-112414-054813 Francez-Charlot, A., Frunzke, J., Reichen, C., Ebneter, J. Z., Gourion, B., & Vorholt, J. A. (2009). Sigma factor mimicry involved in regulation of general stress response. Proceedings of the National Academy of Sciences, 106(9), 3467–3472. https://doi.org/10.1073/pnas.0810291106 Francez-Charlot, A., Kaczmarczyk, A., Fischer, H.-M., & Vorholt, J. A. (2015). The general stress response in Alphaproteobacteria. Trends in Microbiology, 23(3), 164–171. https://doi.org/10.1016/j.tim.2014.12.006 Gottesman, S. (2019). Trouble is coming: Signaling pathways that regulate general stress responses in bacteria. Journal of Biological Chemistry, 294(31), 11685–11700. https://doi.org/10.1074/jbc.REV119.005593 Gottschlich, L., Geiser, P., Bortfeld-Miller, M., Field, C. M., & Vorholt, J. A. (2019). Complex general stress response regulation in Sphingomonas melonis Fr1 revealed by transcriptional analyses. Scientific Reports, 9(1), 9404. https://doi.org/10.1038/s41598-019-45788-7 Herrou, J., Rotskoff, G., Luo, Y., Roux, B., & Crosson, S. (2012). Structural basis of a protein partner switch that regulates the general stress response of α-proteobacteria. Proceedings of the National Academy of Sciences, 109(21). https://doi.org/10.1073/pnas.1116887109 Kaczmarczyk, A., Hochstrasser, R., Vorholt, J. A., & Francez-Charlot, A. (2014). Complex two-component signaling regulates the general stress response in Alphaproteobacteria. Proceedings of the National Academy of Sciences, 111(48). https://doi.org/10.1073/pnas.1410095111 Kaczmarczyk, A., Hochstrasser, R., Vorholt, J. A., & Francez-Charlot, A. (2015). Two-Tiered Histidine Kinase Pathway Involved in Heat Shock and Salt Sensing in the General Stress Response of Sphingomonas melonis Fr1. Journal of Bacteriology, 197(8), 1466–1477. https://doi.org/10.1128/JB.00019-15 Staroń, A., & Mascher, T. (2010). General stress response in α-proteobacteria: PhyR and beyond. Molecular Microbiology, 78(2), 271–277. https://doi.org/10.1111/j.1365-2958.2010.07336.x
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