The extent of β-cell injury determines the regenerative route.
Description
The extent of β-cell number decline in diabetes generates as yet unidentified signals that determine the regenerative mechanism(s) taken. During β-cell loss progression, ranging from mild to moderate and severe, surviving β-cells serve as the primary source for regeneration through β-cell replication and/or
redifferentiation. Only in instances of extreme β-cell injury are non-β-cell sources addressed and neogenesis from progenitor cells and/or reprogramming from non-β-cells occurs.
Acknowledgements
References
Bourgeois, S., Coenen, S., Degroote, L., Heremans, Y., De Leu, N., & Staels, W. (2024). Harnessing beta cell regeneration biology for diabetes therapy. Trends in Endocrinology & Metabolism. Advance online publication. https://doi.org/10.1016/j.tem.2024.03.006
Get started with this template for freeDon’t start from scratch.
Create professional scientific illustrations quickly and easily, even without any design expertise
- Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
- Create figures that effectively communicate your research in half the time using our editable icons.
- Use our PDB tool to quickly generate and customize protein structures
.gif)
