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This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The estrus cycle of mice can be divided into 4 stages: proestrus, estrus, metestrus, and diestrus. Each stage last about one day and has different characteristics. During the estrus cycle, the sex hormones estrogen and progesterone fluctuate and the vaginal cytology varies between nucleated endothelial cells, folded endothelial cells and neutrophils. When ovulation takes place, the endometrium proliferates and when progesterone levels and neutrophil numbers are high, the window of implantation occurs.