The Elderly Lung Mucosa Environment Increases Susceptibility to M.tb Infection
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Soluble innate compounds in the alveolar lining fluid (ALF) play a significant role in controlling microbial infections by the recognition of pathogens and proper activation of subsequent innate and adaptive immune responses. As we age, changes in ALF soluble components (such as increased levels of oxidized and dysfunctional innate proteins) are contributing factors to the increased susceptibility of respiratory diseases, in particular tuberculosis caused by Mycobacterium tuberculosis (M.tb).
Acknowledgements
References
Moliva, J.I., et al.. (2019) The Lung Mucosa Environment in the Elderly Increases Host Susceptibility to Mycobacterium tuberculosis Infection. JID 2019:220. https://doi.org/10.1093/infdis/jiz138
Moliva, J.I., et al.. (2014) Molecular composition of the alveolar lining fluid in the aging lung. AGE (2014) 36:1187–1199. https://doi.org/10.1007/s11357-014-9633-4
Lafuse, W.P., et al.. (2019) Identification of an Increased Alveolar Macrophage Subpopulation in Old Mice That Displays Unique Inflammatory Characteristics and Is Permissive to Mycobacterium tuberculosis Infection. J Immunol. 2019 Oct 15;203(8):2252-2264. https://doi.org/10.4049/jimmunol.1900495
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