The effect of pericellular oxygen levels in cultured cells
Description
The figure displays the effect of normoxia and hyperoxia on iron uptake machinery, nitric oxide production, and redox levels. In the normoxia panel (5 kPa), it depicts lower iron requirements and balanced nitric oxide and redox levels. The hyperoxia panel (18 kPa) illustrates a higher demand for iron, influencing nitric oxide generation and redox states. The figure emphasizes the role of oxygen conditions in iron homeostasis and cellular metabolism.
Acknowledgements
References
Sevimli G, Smith MJ, Caglar TA, Bilir Ş, Secilmis M, Altun HY, Yigit EN, Yang F, Keeley TP, Malli R, Öztürk G, Mann GE, Eroglu E. Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels. Redox Biol. 2022 Jul;53:102319. doi: 10.1016/j.redox.2022.102319.
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