The different aspects that could be integrated to target Mycobacterium tuberculosis persistence.
Description
Epigenetic Modifications by Mtb: Mtb alters host cell epigenetics to enhance its survival. Targeting these changes offers therapeutic potential.
Personalized Microbiota Therapy: Customized microbiota adjustments can counteract imbalances induced by Mtb or its treatment, aiding TB control and preventing opportunistic infections.
Genetic Interactions in Mtb: Mtb genes interact across pathways, enhancing pathogen persistence. Understanding these interactions is crucial for TB intervention.
Acknowledgements
References
[1] S. Fatima et al., “Epigenetic code during mycobacterial infections: therapeutic implications for tuberculosis,” The FEBS Journal, vol. 289, no. 14, pp. 4172–4191, Sep. 2021, doi: 10.1111/febs.16170.
[2] C. Lange et al., “Perspectives for personalized therapy for patients with multidrug‐resistant tuberculosis,” Journal of Internal Medicine, vol. 284, no. 2, pp. 163–188, Jul. 2018, doi: 10.1111/joim.12780.
[3] H. Joshi, D. Kandari, and R. Bhatnagar, “Insights into the molecular determinants involved in Mycobacterium tuberculosis persistence and their therapeutic implications,” Virulence, vol. 12, no. 1, pp. 2721–2749, Nov. 2021, doi: 10.1080/21505594.2021.1990660.
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