TAZ-induced Cybb contributes to liver tumor formation in non-alcoholic steatohepatitis
Description
TAZ in pre-tumor NASH-hepatocytes, via induction of Cybb and NOX2-mediated DNA damage, contributes to subsequent HCC tumor development. These findings illustrate how MASH provides a unique window into the early molecular events that can lead to tumor formation and suggest that NASH therapies targeting TAZ might also prevent MASH-HCC.
Acknowledgements
References
Wang X. J Hepatol. 2022 Apr;76(4):910-920. doi: 10.1016/j.jhep.2021.11.031. Epub 2021 Dec 11.
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