T Cell Differentiation into Various Functional Subtypes
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Polarizing cytokines activate distinct transcription factor (TF) cascades within naïve CD4+ T cells and influence T cell differentiation into distinct effector T cell subtypes. T helper (Th) 1, Th2, and Th17 effector cell subsets are characterized by the expression of distinct TFs, namely T-bet, GATA3 and RORγt, respectively, that drive the production of signature effector cytokines specific to each Th subset. These effector cytokines are important in mediating responses to an array of pathogens.
Acknowledgements
References
Bruce M Hall. (2015) T Cells: Soldiers and Spies--The Surveillance and Control of Effector T Cells by Regulatory T Cells. Clin J Am Soc Nephrol.. https://pubmed.ncbi.nlm.nih.gov/25876770/
Akihiko Yoshimura et. al. (2012) SOCS, Inflammation, and Autoimmunity. Front Immunol.. https://pubmed.ncbi.nlm.nih.gov/22566904/
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