T cell activation and differentiation
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Signal 1 (binding of the T-cell receptor (TCR) to the peptide-MHCII complex on the antigen-presenting cell (APC) surface) and signal 2 (binding of the T-cell co-receptor CD28 to CD80/CD86 on the APC surface) are required for T-cell activation. The binding of polarizing cytokines to their respective receptor on the T cell surface represents signal 3. Different combinations of these cytokines influence T cell differentiation into distinct effector T cell subtypes that produce signature cytokines.
Acknowledgements
References
Florian Guisier et. al. (2020) Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment. Adv Exp Med Biol.. https://pubmed.ncbi.nlm.nih.gov/32036603/
Bruce M Hall. (2015) T Cells: Soldiers and Spies--The Surveillance and Control of Effector T Cells by Regulatory T Cells. Clin J Am Soc Nephrol.. https://pubmed.ncbi.nlm.nih.gov/25876770
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