Suppression of Inflammasome by IRF4 and IRF8 is Critical for T Cell Priming
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Macrophages and dendritic cells perform varying functions in response to virulent bacterial products. Macrophages undergo inflammasome activation resulting in membrane rupture, cell death, and local inflammation. In contrast, dendritic cells (DCs) act as professional antigen-presenting cells and must maintain membrane integrity in order to prime naive T cells against invading pathogens. To do so, DCs must suppress inflammasome activation, which was found to be mediated by conventional DC expression of IRF4/8.
Acknowledgements
References
McDaniel, MM et. al. (2020) Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming. Cell Reports. https://www.ncbi.nlm.nih.gov/pubmed/32375053
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