Structure of HER2 transmembrane glycoprotein
Description
In the extracellular part of the receptor, LD1 and LD2 are sections that bind to ligands. CR1 and CR2 are regions rich in cysteine, a type of amino acid. TM stands for transmembrane, indicating short sections that cross the cell membrane. TK refers to a catalytic tyrosine kinase, an enzyme that adds phosphate groups to tyrosine residues, a process called phosphorylation. CT is the carboxyl-terminal tail, a part of the protein structure. The circled Ps represent phosphorylation sites.
Acknowledgements
References
Lv, Q., Meng, Z., Yu, Y., Jiang, F., Guan, D., Liang, C., Zhou, J., Lu, A., & Zhang, G. (2016). Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer. International Journal of Molecular Sciences 2016, Vol. 17, Page 2095, 17(12), 2095. https://doi.org/10.3390/IJMS17122095
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