Striatal Acetylcholine - Midbrain Dopamine Dynamics

Description

Following a salient sensory stimulus, a unique dynamic occurs between striatal cholinergic interneurons (CINs) and midbrain dopaminergic neurons (DANs). CINs exhibit an initial excitation during which they release acetylcholine (ACh) which stimulates the axons of DANs. DANs release dopamine (DA) which inhibits CINs, resulting in a CIN pause. Once DA levels decrease, CINs rebound from the inhibition.

Acknowledgements

References

Aosaki, T., Miura, M., Suzuki, T., Nishimura, K., & Masuda, M. (2010). Acetylcholine–dopamine balance hypothesis in the striatum: An update. Geriatrics & gerontology international, 10, S148-S157. Bech, P., Crochet, S., Dard, R., Ghaderi, P., Liu, Y., Malekzadeh, M., ... & Sourmpis, C. (2023). Striatal Dopamine Signals and Reward Learning. Function, 4(6), zqad056. Martyniuk, K. M., Torres-Herraez, A., Lowes, D. C., Rubinstein, M., Labouesse, M. A., & Kellendonk, C. (2022). Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels. Elife, 11, e76111.

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