Spleen tyrosine kinase (Syk)-mediated mechanism of action of caspofungin in SARS-CoV-2
Description
Syk inhibitors suppress macrophage activation and overproduction of proinflammatory cytokines, thrombus formation, and the release of neutrophil extracellular traps (NETs) caused by SARS-CoV-2, and remove overexpressed mucin-1 from the cell membrane in lung epithelial cells.
Acknowledgements
References
Itoh K, et al. Implications of empirical administration of caspofungin in COVID-19 complicated fungal infections. Front Cell Infect Microbiol. 2023;13:1269543.
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