Smad7 Gene Delivery Prevents Muscle Wasting Associated with Cancer in Mice
Description
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Recombinant adeno-associated viral vectors (rAAV vectors) were used to increase expression of Smad7 in skeletal muscles. SMAD7 acts as an intracellular negative regulator that prevents SMAD2/3 activation. In mouse models of cachexia, rAAV:Smad7 prevented wasting of skeletal muscles. Mechanistically, rAAV:Smad7 administration abolished SMAD2/3 signaling downstream of ActRIIB and inhibited expression of protein degradation genes while increasing expression of protein synthesizing genes.
Acknowledgements
References
Catherine. E.. (2016) 348ra98. Science Translational Medicine. https://stm.sciencemag.org/content/8/348/348ra98
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