Signaling pathways underlying Trans Vaccenic acid(TVA) and/or S63845-induced apoptosis in NPC cells
Description
1.TVA promotes NPC apoptosis by targeting the Akt/Bad signaling pathway.
2.TVA treatment induced Mcl-1 expression.
3. Mcl-1 inhibitor S63845 combinated with TVA have a synergistic effect.
4. Specific activation of Akt inhibited apoptosis and significantly attenuated the inhibitory effect of TVA.
Acknowledgements
References
Song, J., Wang, Y., Fan, X., Wu, H., Han, J., Yang, M., ... & Nie, G. (2019). Trans-vaccenic acid inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via a mitochondrial-mediated apoptosis pathway. Lipids in health and disease, 18, 1-9.
Fan, H., Xia, S., Xiang, J., Li, Y., Ross, M. O., Lim, S. A., ... & Chen, J. (2023). Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity. Nature, 623(7989), 1034-1043.
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