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This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Nanodiscs (high-density lipoproteins) have gained attention in nanomedicine in the past few years. These discoidal-shaped structures exist within our body and function in the reverse cholesterol pathway as transporters. Recently, synthetic HDL have been developed to remove cholesterol in atherosclerotic patients. Nanodiscs' small size and features have also prompted investigations toward the use of sHDL as therapeutic drug carriers and gene expression modulators.