Secretin Mode of Action in a large cholangiocyte.
Description
A. Secretin binds to the G-protein coupled receptor. B. Triggers cyclic AMP production. C. cAMP stimulates phosphorylation of protein kinase A. D. Cystic fibrosis transmembrane conductance regulator activated = efflux of Cl- ions. E. Sodium/bicarbonate symport activated = influx of bicarbonate. F. Anion exchanger 2 secretes intracellular bicarbonate. G. Exocytosis of intracellular vesicles = CFTR, AE2 and aquaporin 1 which are inserted into the apical membrane. H. Water efflux.
Acknowledgements
References
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Bai, J. J., C. Da Tan, and B. K. C. Chow. 2017. Secretin, at the hub of water-salt homeostasis. Am J Physiol Renal Physiol. 312(5):852–860. doi:10.1152/ajprenal.00191.2015
Chu, J. Y. S., C. Y. Y. Cheng, V. H. Y. Lee, Y. S. Chan, and B. K. C. Chow. 2011. Secretin and body fluid Homeostasis. Kidney Int. 79(3):280–287. doi:10.1038/ki.2010.397
Lam, I. P. Y., F. K. Y. Siu, J. Y. S. Chu, and B. K. C. Chow. 2008. Multiple Actions of Secretin in the Human Body. Int Rev Cytol. 265:159–190. doi:10.1016/S0074-7696(07)65004-9
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