Secondary lesion of TBI
Description
Blood brain barrier (BBB) dysfunction caused by TBI allows transmigration of activated leukocytes into the injured brain. Activated leukocytes, microglia and astrocytes produce ROS (reactive oxygen species) and inflammatory molecules such as cytokines and chemokines that contribute to demyelination and disruption of axonal cytoskeleton, leading to axonal swelling and accumulation of transport proteins at the terminals, hence compromising neuronal activity.
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