Schematic representation showing synergistic interplay between muscle and brown fat development.
Description
During development, BAT and SkM share a common Myf5+ progenitor cell while WAT originates from Myf5− progenitors. PRDM16 is a key transcriptional switch that induces commitment towards the BAT lineage while inhibiting the SkM lineage. Thyroid hormone and sympathetic innervations promote mitochondrial metabolism and program both sites to carry out adaptive thermogenesis. All these features reflect that BAT is developmentally and functionally closer to SkM than WAT.
Acknowledgements
References
1. Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., ... & Spiegelman, B. M. (2008). PRDM16 controls a brown fat/skeletal muscle switch. Nature, 454(7207), 961-967.
2. Crisan, M., Casteilla, L., Lehr, L., Carmona, M., Paoloni-Giacobino, A., Yap, S., ... & Giacobino, J. P. (2008). A reservoir of brown adipocyte progenitors in human skeletal muscle. Stem cells, 26(9), 2425-2433.
3. Seebacher, F. (2018). The evolution of metabolic regulation in animals. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 224, 195-203.
4. Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009). Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex. Nature, 460(7259), 1154-1158.
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