Schematic Representation of the Canonical JAK-STAT Signaling Pathway
Description
(A) Various extracellular cytokines and growth factors use transmembrane receptors to initiate cellular signaling and gene transcription. (B) Cytokine binding alters the receptor’s conformation, leading to JAK dimer phosphorylation. This induces STAT dimerization and phosphorylation, allowing STAT to migrate to the nucleus and mediate gene transcription. (C) JAK-STAT pathway inhibitors (iJAK) block JAK phosphorylation, disrupting cytokine or growth factor signaling.
Acknowledgements
References
Miot HA, Criado PR, Castro CC, Ianhez M, Talhari C, Ramos P. JAK-STAT pathway inhibitors in dermatology. An Bras Dermatol. 2023;98:656---77.
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