SAMHD1 Reduces Efficiency of Nucleoside Analog Ara-C Against AML Cells

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. This figure illustrates how SAMHD1, a dNTP hydrolase, reduces the efficiency of nucleoside analog, Ara-C, against acute myeloid leukemia (AML) cells. Once inside the AML cells, the inactive Ara-C gets triphosphorylated (Ara-CTP). In SAMHD1-low AML cells, Ara-CTP inhibits DNA replication, leading to apoptosis. In SAMHD1-high AML cells, Ara-CTP is recognized as a SAMHD1 substrate and is converted back to inactive Ara-C. Here, DNA replication progresses and the cells are protected from apoptosis.

Acknowledgements

References

Schneider, C. et. al.. (2017) SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.. Nature Medicine. https://www.nature.com/articles/nm.4255

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