Salmonella Pathogenesis
Description
Salmonella's journey into the body involves breaching multiple barriers before reaching the lamina propria to cause infection. It can enter via ingestion, inhalation, or direct contact, bypassing defences like the gut epithelium and immune responses to cause infection in the deeper tissue layers.
Acknowledgements
References
Haraga, A., Ohlson, M. B., & Miller, S. I. (2008). Salmonellae interplay with host cells. Nature Reviews Microbiology, 6(1), 53–66. https://doi.org/10.1038/nrmicro1788
Hume, P., Singh, V., Davidson, A. C., & Koronakis, V. (2017). Swiss Army Pathogen: The Salmonella Entry toolkit. Frontiers in Cellular and Infection Microbiology, 7. https://doi.org/10.3389/fcimb.2017.00348
Garai, P., Gnanadhas, D. P., & Chakravortty, D. (2012). Salmonella entericaserovars Typhimurium and Typhi as model organisms. Virulence, 3(4), 377–388. https://doi.org/10.4161/viru.21087
Wang, M., Qazi, I. H., Wang, L., Zhou, G., & Han, H. (2020). Salmonella virulence and immune escape. Microorganisms, 8(3), 407. https://doi.org/10.3390/microorganisms8030407
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