Roles of the Complement Cascade in Innate Immunity
Description
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Complement is a collection of soluble proteins undergoing a complex series of combination and cleavage reactions. Ultimately, the major end products resulting from the cleavage of C3 and C5 each play important roles in the innate immune system. C3a and C5a function as anaphylatoxins, recruiting neutrophils and monocytes; C3b serves as an important opsonin while also amplifying the signal of the entire cascade; and finally, C5b combines with other proteins to form the membrane attack complex.
Acknowledgements
References
Parham, P. (2015) Innate Immunity: The Immediate Response to Infection.. The Immune System (Fourth Edition).
Murphy, KP. (2012) The Complement System and Innate Immunity. Janeway's Immunobiology (Eighth Edition).
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