Role of Lipin-1 in Modified-LDL Induced Pro-Inflammatory Response

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Macrophage pro-inflammatory responses play a critical role in atherosclerotic progression. Uptake of modified low-density lipoproteins (modLDL) causes a series of lipid metabolic processes that lead to the formation of lipid-laden macrophages. Lipin-1 catalyzes the conversion of phosphatidic acid (PA) to Diacylglycerol (DAG). DAG is a key substrate for the synthesis of lipid droplets and a signaling molecule that promotes pro-inflammatory gene expression.

Acknowledgements

References

Vozenilek A.E. et. al.. (2017) Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein–Induced Proinflammatory Signaling and Atherosclerosis 38:324–334. Arteriosclerosis, Thrombosis, and Vascular Biology. https://www.ahajournals.org/doi/10.1161/ATVBAHA.117.310455 Balboa M.A. et. al.. (2019) The role of lipins in innate immunity and inflammation 1864:1388-1981. BBA - Molecular and Cell Biology of Lipids. https://doi.org/10.1016/j.bbalip.2019.06.003 Zhang P. et. al.. (2017) Lipin proteins and glycerolipid metabolism: Roles at the ER membrane and beyond 1859:1583-1595. Biochimica et Biophysica Acta. https://doi.org/10.1016/j.bbamem.2017.04.007 Ghosh S. et al.. (2010) Macrophage cholesteryl ester mobilization and atherosclerosis 52:1-10. Vascular Pharmacology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823947/

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