Role of Funny Channels in Cardiac Pacemaker Activity
Description
The "funny" channels are cAMP-gated channels that allow the cardiac pacemaker membrane current to "float" upwards until threshold is reached. The αi subunit of the muscarinic acetylcholine receptor-associated G protein inhibits the formation of cAMP and the membrane potential "floats" upward more slowly. The αs subunit of the β-adrenergic receptor stimulates the formation of cAMP and the membrane potential "floats" upward more quickly.
Acknowledgements
References
DiFrancesco D (2010). The role of the funny current in pacemaker activity. Circ Res 106:434-436. https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.109.208041
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