Role of Epg5 in the autophagosome maturation
Description
Schematic description of the molecular role of Epg5 in the fusion between autophagosome and lysosome. The presence of SNAP29 and STX17 on the membrane of the autophagosome promotes the fusion with the late endosome/lysosome, with a mechanism Rab7 and Epg5 dependent.
Acknowledgements
References
Cullup T., et al., 2013. Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy.
Tian Y., et al., 2010. C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms.
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