Role of Ambra1 in autophagy induction
Description
In basal conditions, AMBRA1 is bound to the dynein light chains of the dynein motor complex, together with Beclin-1 and Vps34. Once autophagy is induced, ULK1 mediates the phosphorylation of AMBRA1, thus promoting the release of the complex with Beclin-1 and Vps34 from the dynein light chain and its subsequent translocation to the ER.
Acknowledgements
References
Di Bartolomeo et al., 2010. The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy.
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