Role of 14-3-3ε in the Pathology of Osteoarthritis
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
In osteoarthritis (OA)14-3-3ε acts as an alarmin, an endogenous molecule released in response to different types of damage that binds to pattern recognition receptors (PRR) of different cells and that can drive an inflammatory or regenerative response. As a result, alarmins can polarise cells such as macrophages and fibroblasts and increase the production of proinflammatory mediators and metalloproteases, which lead to cartilage destruction and joint damage, therefore sustaining inflammation and OA pathology.
Acknowledgements
References
Millerand, M., Sudre, L., Nefla, M., Pène, F., et al. Activation of innate immunity by 14-3-3 ε, a new potential alarmin in osteoarthritis. Osteoarthritis and cartilage, 28(5), 646–657 (2020). https://doi.org/10.1016/j.joca.2020.03.002
Nefla, M., Holzinger, D., Berenbaum, F. et al. The danger from within: alarmins in arthritis. Nat Rev Rheumatol 12, 669–683 (2016). https://doi.org/10.1038/nrrheum.2016.162
Priam, S., Bougault, C., Houard, X., et al. Identification of soluble 14-3-3∊ as a novel subchondral bone mediator involved in cartilage degradation in osteoarthritis. Arthritis and rheumatism, 65(7), 1831–1842 (2013). https://doi.org/10.1002/art.37951
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