Retina Regeneration

Description

Müller glial cells play a crucial role in the process of retina regeneration. In zebrafish, upon injury to the retina, Müller glia become activated (1) and proliferate by asymmetrical cell division to generate neural progenitor cells (2) that migrate to the injured layer (3) and differentiate into the damaged retinal cell type (4). In mammals, Müller glia become activated in response to retinal injury but have limited proliferative ability and do not give rise to retinal progenitor cells.

Acknowledgements

Ana Teresa Tavares (Creator) Raquel Lourenço Rita Gorgulho

References

Goldman D. (2014). Müller glial cell reprogramming and retina regeneration. Nature reviews. Neuroscience, 15(7), 431-442. https://doi.org/10.1038/nrn3723 Lahne, M., Nagashima, M., Hyde, D. R., & Hitchcock, P. F. (2020). Reprogramming Müller Glia to Regenerate Retinal Neurons. Annual review of vision science, 6, 171-193. https://doi.org/10.1146/annurev-vision-121219-081808

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