Rescue of Influenza A Virus from Recombinant DNA
Description
Reverse genetics for negative-strand RNA viruses, first developed for influenza virus has dramatically changed our understanding of the replication cycles of these viruses. In addition, this methodology has allowed genetic manipulation of viral genomes in order to generate new viruses, which can be used as live, attenuated vaccines or vectors to express heterologous proteins. Reverse genetics methodology has been used in engineering viruses with specific characteristics to enable their study.
Acknowledgements
References
Fodor, E., Devenish, L., Engelhardt, O. G., Palese, P., Brownlee, G. G., & García-Sastre, A. (1999). Rescue of influenza A virus from recombinant DNA. Journal of virology, 73(11), 9679-9682.
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