Regulation by the FH family proteins of the complement alternative pathway activation.
Description
FH is the main regulator of the AP both in fluid phase and on cell surfaces. It acts as a cofactor for factor I proteolytic cleavage of C3b, accelerates the dissociation of the C3/C5 convertases and competes with factor B for C3b binding. The FHRs may display both inhibiting and promoting AP activities. FHR-1 and FHR-5 act as inhibitors of the C5 convertases. Conversely, surface-bound FHRs bind C3b from the fluid phase and promote AP activation.
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