Radiotherapy-Resistant Breast Cancer Patients: Screening and Therapeutic Approach

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. About 80% of breast cancer (BCa) patients benefit from radiotherapy (RT). However, advanced invasive tumors can develop resistance. The majority of BCa patients receive RT without considering disease biology. Consequently, radioresistant BCa patients also receive RT even though they will not respond. Therefore, there is an urgent need to unveil the mechanisms underlying BCa radioresistance to allow screening of RT-resistant BCa patients and improve the clinical management towards therapy response.

Acknowledgements

References

Langlands, F.E.. (2013) Breast Cancer subtypes: response to radiotherapy and potential radiosensitisation. British Journal of Radiology. doi: 10.1259/bjr.20120601 Giordano, S. H.. (2018) NCCN Guidelines Updates: Breast Cancer. Journal of the National Comprehensive Cancer Network. doi.org/10.6004/jnccn.2018.0043 Early Breast Cancer Trialists' Collaborative Group. (1995) Effects of radiotherapy and surgery in early breast cancer. An overview of the randomized trials. New England Journal of Medicine. doi: 10.1056/NEJM199511303332202 Delaney, G.. (2005) The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer. doi: 10.1002/cncr.21324

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