Protumorigenic effects of aging-associated metabolism in the epithelium
Description
Aging promotes metabolic and redox rewiring, including an increase in ROS and the induction of a Warburg-like metabolism. On the other hand, aging also leads to the suppression of antitumorigenic pathways, including the inhibition of sirtuins via a decrease in NAD+. Together these age-induced alterations create a metabolic environment in aged epithelial cells that empowers carcinogenesis.
Acknowledgements
References
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